I had a chain and padlock - connected round the trailer and round a big shed pile.
It was stolen - I think they simply drove off, and the sudden shock broke the padlock hasp.
The hasp was hardened steel - which I believe makes it brittle, then easily broken.
THey probably (in the dark) didnt even know the chain was there.
A chain and padlock is only as strong as its weakest place.
A wheel clamp might deter, but must be the strongest - probably SAS clamp. I have seen cheaper clamps, that I think could be levered off with a steel bar.
Things that stop the coupling being used, might deter, but I think a prepared and determined thief will get around that by either cutting with a grinder or big bolt cutter, or simply tie the trailer coupling to the vehicle ball.
THe best thing I know of, would be a very strong chain and lock. Which I have - 14mm gauge chain (from Ropes chains and anchors) with a super strong lock LOckwood 29 series Steel Case Monoblock Padlock.

This is too small, but I couldnt make it bigger.
Further - I think the best deterrent by far - is to put the boat away from the road frontage, preferably out of sight from the road. In fact, my current boat is behind our house and out of view from the road; and near to 3 houses. I only have a pin with padlock, stopping the trailer coupling being used; not much, but I dont believe its going to be stolen from there, when there are plenty others in a far easier place.
And obviously need insurance cover. I have had boats stolen twice - and in each case the police did eventually find and recover both.